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Platelets play a significant role in hemostasis.
To study their activity still in the first twenty-four hours of paroxysmal atrial fibrillation (PAF).
Materials and methods
We measured plasma levels of β-thromboglobulin (β-TG) and platelet factor-4 (PF-4), main markers of platelet activity, in 51 non-anticoagulated patients (26 men, 25 women; mean age 59.84±1.60) with PAF duration < 24 hours and in 52 controls (26 men, 26 women; mean age 59.50±1.46) matched by age, gender, concomitant diseases and their treatment. The markers were examined once per each participant by chromogenic assays.
Plasma levels of β-TG were significantly higher in the patient group compared to controls (25.04 ± 1.10 IU/mL vs 14.97 ± 0.46 IU/mL, p<0.001). Compared to controls, patients with PAF had substantially higher levels of PF-4 (8.07 ± 0.44 IU/mL vs 3.99 ± 0.27 IU/mL, p<0.001).
Platelet activity is significantly increased in the first twenty-four hours of PAF clinical manifestation that is a predisposition to the development of hypercoagulable state still in that very early stage of the disease.