Author + information
Prothrombin fragments 1+2 (F1+2) and fibrinopeptide A (FpA) are early markers for blood coagulation abnormalities and in this sense their study is of research and clinical interest in paroxysmal atrial fibrillation (PAF).
To study F1 + 2 and FpA plasma levels in patients with clinical manifestation of PAF episodes <24 hours.
Materials and Methods
We studied 51 non-anticoagulated patients (26 men, 25 women; mean age 59.84 ± 1.60 years) with PAF duration<24 hours, and 52 controls (26 men, 26 women; mean age 59.50 ± 1.46 years). Plasma levels of F1+2 and FpA were examined once per each participant by enzyme-linked immunoassays.
Plasma levels of F1+2 were significantly higher in the patient group compared to controls (183.40 pmol/L ± 8.38 pmol/L vs 292.61 pmol/L±14.03 pmol/L; p <0.001). Compared to controls, patients with PAF had substantially higher levels of FpA (3.09 mcg.mL±0.15 mcg/mL vs 4.47 mcg/mL ± 0.25 mcg/mL, p <0.001).
The results give us grounds to assume that blood coagulation is significantly activated and there is a tendency for hypercoagulability even during the first twenty-four hours of PAF.