Table 2

Clinical and Cardiac Imaging Characteristics of 173 AC Patients Divided by Short and Long Exercise Duration

≤2.5 h/week (n = 87)>2.5 h/week (n = 86)p ValueAdjusted OR (95% CI)p Value
Age, yrs42 ± 1839 ± 140.32
BSA, m21.9 ± 0.21.9 ± 0.20.69
Female52 (60)24 (28)<0.0010.5 (0.2–1.1)0.08
Probands34 (39)57 (84)<0.001
High intensity25 (29)66 (77)<0.0014.6 (2.0–11)<0.001
VA
 Total VA27 (31)56 (65)<0.0011.6 (0.6–3.9)0.35
  ACA4 (5)13 (16)0.02
  VT19 (22)51 (61)<0.001
  ICD therapy10 (12)39 (46)<0.001
 Age at VA, yrs46 ± 1638 ± 150.03§1.0 (0.9–1.0)0.06
Cardiac imaging
 LV dysfunction24 (29)42 (49)0.0081.3 (0.6–2.8)0.54
  EF, %58 ± 554 ± 90.002
  GLS, %−19.5 ± 3.0−18.3 ± 3.50.02
 RV dilation53 (63)75 (87)<0.0012.5 (0.9–6.4)0.07
  RVD, mm40 ± 744 ± 90.001
  RVOT, mm33 ± 738 ± 90.001
  CMR RVEDVi, ml/m2103 ± 41109 ± 320.51
 RV dysfunction47 (53)62 (71)0.020.9 (0.4–2.1)0.81
  FAC, %41 ± 1037 ± 100.01
  TAPSE, mm20 ± 519 ± 60.36
  CMR RV EF, %49 ± 1246 ± 110.30

Values are mean ± SD, or n (%). Unpaired Student’s t-test, chi-squared, Fisher exact test, and multivariable logistical regression.

ACA = aborted cardiac arrest; CI = confidence interval; CMR = cardiac magnetic resonance imaging; EF = ejection fraction; FAC = fractional area change; GLS = global longitudinal strain; ICD = implantable cardioverter-defibrillator; LV = left ventricle; OR = odds ratio; RV = right ventricle; RVD = RV diameter; RVEDVi = RV end-diastolic volume indexed; RVOT = RV outflow tract; TAPSE = tricuspid annular plane systolic excursion; VT = ventricular tachycardia; other abbreviations as in Table 1.

  • Multivariable logistical regression including significant variables from univariable analyses and age.

  • Proband status was not retained in multivariable analyses because of multicollinearity with VA.

  • Parameters used to define VA, LV dysfunction, RV dilation, and RV dysfunction were not retained in multivariable analysis.

  • § Age at VA was adjusted in a separate model without age, because of multicollinearity.