Table 3

Clinical and Cardiac Imaging Characteristics of 173 AC Patients and Mutation Carriers With History of Low-Intensity and High-Intensity Exercise

≤6 METs (n = 82)>6 METs (n = 91)p ValueAdjusted OR (95% CI)p Value
Age, yrs41 ± 1740 ± 150.54
BSA, m21.9 ± 0.21.9 ± 0.20.61
Female52 (63)24 (26)<0.0010.3 (0.1–0.6)0.003
Probands22 (27)69 (76)<0.001
Long duration20 (24)66 (73)<0.0014.7 (2.0–11)<0.001
VA
 Total VA16 (20)67 (74)<0.00114.1 (5.1–39)<0.001
  ACA4 (5)13 (15)0.03
  VT12 (15)58 (66)<0.001
  ICD therapy6 (7)43 (49)<0.001
 Age at VA, yrs45 ± 1439 ± 160.20
Cardiac imaging
 LV dysfunction21 (27)45 (50)0.0021.4 (0.6–3.5)0.45
  EF, %58 ± 555 ± 90.01
  GLS, %−19.9 ± 2.6−18.0 ± 3.5<0.001
 RV dilation52 (64)76 (85)0.0010.7 (0.2–1.8)0.42
  RVD, mm39 ± 745 ± 9<0.001
  RVOT, mm34 ± 637 ± 90.004
  CMR RVEDVi, ml/m296 ± 30117 ± 390.02
 RV dysfunction42 (52)67 (76)0.0010.8 (0.3–2.2)0.70
  FAC, %42 ± 936 ± 10<0.001
  TAPSE, mm21 ± 518 ± 60.005
  CMR RV EF, %50 ± 1145 ± 120.07

Values are mean ± SD, or n (%). Unpaired Student’s t-test, chi-squared, Fisher exact test, and multivariable logistical regression.

Abbreviations as in Tables 1 and 2.

  • Multivariable logistical regression including significant variables from univariable analyses and age.

  • Proband status was not retained in multivariable analyses because of multicollinearity with VA.

  • Parameters used to define VA, LV dysfunction, RV dilation, and RV dysfunction were not retained in multivariable analysis.