Table 2

Obesity and AF—Case Control Studies

First Author (Ref. #)Cohort SourceDates of StudyCountrySubjects (% Women)Mean Age (yrs)Body Mass Index (kg/m2)Body Mass Index Data ReportedCases of AF (%)AF DiagnosisOther Covariates in Model
Krahn et al. (32)Manitoba Follow-Up Study1948–1992Canada3,983 (0%)33Mean 23Categorical299 (7.5%)ECGAge, hypertension, ischemic heart disease, congestive heart failure, valvular disease, cardiomyopathy, palpitations, supraventricular rhythm disturbance, ventricular rhythm disturbance
Hanna et al. (33)ADVANCENT Registry2003–2004United States25,268 (28%)66Mean 28.7Continuous7,027 (28%)Patient interview, ECG, and medical recordsAge, sex, hypertension, diabetes, left ventricular ejection fraction, NYHA functional class, etiology of heart failure, medication use
Dublin et al. (34)Group Health Cooperative2001–2002United States1,132 (58%)71780 (69%) overweight or obeseContinuous and categorical425 (38%)Health care registry and medical recordsAge, sex, hypertension, hypertension duration, systolic blood pressure, diastolic blood pressure, diabetes, diabetes duration, hyperlipidemia, total and HDL cholesterol levels
De Bacquer et al. (35)Belgian Interuniversity Research on Nutrition and Health Survey1980–1996Belgium160 (45%)64Mean 28Continuous40 (25%)ECGSystolic blood pressure, ischemic ECG changes, P-wave duration, P-wave morphology
Umetani et al. (36)University of Yamanashi Hospital2001–2005Japan592 (41%)63Mean 23Categorical32 (5.4%)ECGHypertension, diabetes, HDL cholesterol, triglycerides
Yap et al. (37)Singapore Longitudinal Aging Study2008Singapore1,839 (62%)≥5591 (5%) obeseCategorical26 (1.4%)ECGAge, sex, hypertension, stroke, myocardial infarction, heart failure, diabetes, smoking
Zhang et al. (38)China Multicentre Collaborative Study of Cardiovascular Epidemiology2004China18,615 (56%)61Mean 24Continuous and categorical194 (1.0%)Patient interview or ECGAge, left ventricular hypertrophy, smoking, alcohol, myocardial infarction, diabetes
Haywood et al. (39)Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial1994–2002United States39,056 (46%)≥5516,299 (42%) obeseCategorical423 (1.1%)ECGAge, sex, race, diabetes, coronary heart disease, left ventricular hypertrophy, hypertension, chronic kidney disease, HDL cholesterol, smoking, medication use, hypokalemia
Minami et al. (40)Kanazawa Social Insurance Hospital1998–2006Japan207 (0%)57Mean 23Continuous69 (33.3%)ECGAge, systolic blood pressure, cardiomegaly, alcohol, total cholesterol, gamma-glutamyl transpeptidase, uric acid, fasting plasma glucose, red blood cell count, hemoglobin, smoking
Bonhorst et al. (41)The FAMA Study2010Portugal10,447 (55%)59Mean 27Continuous261 (2.5%)ECGNone
Suzuki et al. (42)Shinken Database2004–2008Japan4,719 (45%)54Mean 23Categorical577 (12.2%)ECG and medical recordsAge, sex, height, left atrial dimension
Soliman et al. (43)Chronic Renal Insufficiency Cohort2001–2008United States3,267 (46%)59Mean 32Continuous602 (18%)ECG or patient interviewAge, sex, ethnicity, study center
Long et al. (44)Guangzhou Biobank Cohort Study2003–2006China19,964 (72%)63Mean 23Continuous and categorical159 (0.8%)ECGAge, sex, alcohol, smoking, hyperthyroidism, diabetes, hypertension, total cholesterol
Hodgkinson et al. (45)General Practice Research Database1987–2007United Kingdom271,812 (50%)74117,456 (57%) overweight or obeseCategorical55,412 (20.4%)Healthcare registryAge, sex, hypertension, heart failure, ischemic heart disease, diabetes, stroke, chronic obstructive pulmonary disease, hyperthyroidism, medication use, smoking, alcohol

ADVANCENT = National Registry to Advance Heart Health; FAMA = Prevalence of Atrial Fibrillation in the Portuguese population aged 40 and over; HDL = high-density lipoprotein; NYHA = New York Heart Association; other abbreviations as in Table 1.