Table 1

Prevalence and Outcomes Related to First-Degree AVB in Population Studies

First Author (Year) (Ref. #)Study TypePopulationNFirst-Degree AVB (ms)First-Degree AVB, n (%)Age (yrs)Mean F/U (yrs)Outcomes Related to First-Degree AVBNotes
Nielsen et al. (2013) (8)Registry analysisECG Copenhagen study 2001–2010288,181≥95% percentile15,262 (5)545.726% increased risk of AF compared to 40th-60th percentile21% increased risk of AF when PR <5th percentile compared to 40th–60th percentile
Rose et al. (1978) (2)Registry analysisNHS Central Register, U.K. male civil servants18,403≥220440 (2)40–645No increase in 5-year CHD mortality
Soliman et al. (2009) (54)Registry analysisAtherosclerotic Risk in Communities study 1987–198915,429Continuous variableN/A546.9741% increased risk of AF for 1-SD increase in PRAs a categorical variable (95th percentile as cutoff) PR was not associated with AF
Blackburn et al. (1970) (35)Registry analysisSeven Countries Study 1958–196412,770≥220Not reported40–595Increased 5-year CHD mortality
Aro et al. (2014) (31)Registry analysisFinnish Social Insurance Institution's CHD study 1966–7210,785>200222 (2)4430No increase in all-cause mortalityFirst-degree AVB normalized in 30% during F/U
Cheng et al. (2009) (11)Registry analysisFramingham Heart Study 1968–1971 original cohort + 1971–1974 1st offspring cohort7,575>200124 (2)4620Increased risk of AF, pacemaker, and all-cause mortality
Soliman et al. (2014) (33)Registry analysisThird National Health and Nutrition Examination Survey 1988–19947,501>200654 (9)5914No increase in all-cause mortalityPR interval <120 ms and long P-wave duration associated with all-cause mortality
Magnani et al. (2011) (18)Registry analysisThird National Health and Nutrition Examination Survey 1988–19947,486≥182
(highest quartile)
1865 (25)608.6Increased all-cause mortality compared to lower 3 quartilesAs a continuous variable, longer PR was not associated with all-cause mortality. Long P-wave was associated with CV mortality.
Perlman et al. (1971) (3)Registry analysisTecumseh Community Health Study 1959–19604,678≥22095 (2)≈404No increase in all-cause mortality or new CHDFirst-degree AVB normalized in 36% during F/U
Mymin et al. (1986) (32)Registry analysisManitoba study 1946–19483,983≥22052 (1)3130No increase in all-cause mortality
Magnani et al. (2013) (19)Registry analysisHealth, Aging and Body Composition Study 1997–19982,722>200339 (13)741046% increase in risk of HFNo increased risk in AF
Erikssen et al. (1984) (34)Registry analysisHealthy male employees in Oslo companies1,832≥22098 (5)507No increase in all-cause mortalityFirst-degree AVB normalized to in 40% during F/U
Packard et al. (1954) (1)Registry analysisU.S. male pilots and flight students 1940–19421,000>20011 (1)2410–12No increase in all-cause mortality or cardiac disease

Values are mean except as noted.

AF = atrial fibrillation; AVB = atrioventricular block; CHD = coronary heart disease; CV = cardiovascular; F/U = follow-up; HF = heart failure.