Table 1

Clinical and Demographic Characteristics of Included Patients

Total
(N = 79,875)
Triple Therapy (Yes/No)p Value
Triple Therapy
(n = 3,568)
No Triple Therapy
(n = 76,307)
Demographics
 Age, yrs72.9 ± 12.372.8 ± 10.472.9 ± 12.40.391
 Male47,593 (59.6)2,460 (68.9)45,133 (59.1)<0.001
Race
 White45,419 (92.7)2,100 (92.7)43,319 (92.7)0.955
 Black2,455 (5.0)129 (5.7)2,326 (5.0)0.127
 Native Hawaiian257 (0.5)4 (0.2)253 (0.5)0.018
 Native American1,203 (2.5)94 (4.2)1,109 (2.4)<0.001
 Asian585 (1.2)38 (1.7)547 (1.2)0.030
 Missing30,903130329,600
Insurance
 Private43,347 (59.3)2,016 (60.7)41,331 (59.3)0.093
 Medicare FFS40,414 (55.3)2,073 (62.5)38,341 (55.0)<0.001
 Medicare managed care8,042 (11.0)355 (10.7)7,687 (11.0)0.554
 Medicaid4,232 (5.8)235 (7.1)3,997 (5.7)0.001
 Military1,443 (2.0)119 (3.6)1,324 (1.9)<0.001
 State538 (0.7)45 (1.4)493 (0.7)<0.001
 Indian Health Service22 (0.0)0 (0.0)22 (0.0)0.623
 Non-U.S.8 (0.0)1 (0.0)7 (0.0)0.310
 None8,521 (11.7)376 (11.3)8,145 (11.7)0.536
 Missing6,8312496,582
Clinical characteristics
 Hypertension72,903 (91.3)3,329 (93.3)69,574 (91.2)<0.001
 Systemic embolization1,866 (2.3)160 (4.5)1,706 (2.2)<0.001
 Heart failure36,336 (45.5)1,970 (55.2)34,366 (45.0)<0.001
 Heart failure encounter within 12 months27,243 (34.1)1,509 (42.3)25,734 (33.7)<0.001
 Stable angina12,074 (15.1)907 (25.4)11,167 (14.6)<0.001
 Dyslipidemia58,127 (72.8)3,055 (85.6)55,072 (72.2)<0.001
 Peripheral arterial disease17,351 (21.7)1,207 (33.8)16,144 (21.2)<0.001
 Diabetes24,677 (30.9)1,614 (45.2)23,063 (30.2)<0.001
 Prior stroke or TIA21,621 (27.1)1,219 (34.2)20,402 (26.7)<0.001
Cardiac events
 History of MI56,630 (70.9)2,483 (69.6)54,147 (71.0)0.078
 History of MI within 12 months50,976 (63.8)1,901 (53.3)49,075 (64.3)<0.001
 History of CABG within 12 months16,605 (20.8)932 (26.1)15,673 (20.5)<0.001
 History of valvular surgery within 12 months3,765 (4.7)157 (4.4)3,608 (4.7)0.366
 History of heart transplant within 12 months50 (0.1)6 (0.2)44 (0.1)0.023
 History of PCI with bare-metal stents within 12 months12,451 (15.6)778 (21.8)11,673 (15.3)0.001
 History of PCI with drug-eluting stents within 12 months27,408 (34.3)1,913 (53.6)25,495 (33.4)<0.001

Values are mean ± SD or n (%).

CABG = coronary artery bypass graft; FFS = fee-for-service; MI = myocardial infarction; PCI = percutaneous coronary intervention; TIA = transient ischemic attack.