Author + information
- Received January 9, 2018
- Revision received February 22, 2018
- Accepted February 22, 2018
- Published online May 2, 2018.
- Mohamad Alkhouli, MDa,b,∗ (, )
- Fahad Alqahtani, MDa,
- Sami Aljohani, MDa,
- Muhammad Alvi, MDc and
- David R. Holmes, MDb
- aDivision of Cardiology, Department of Medicine, West Virginia University School of Medicine, Morgantown, West Virginia
- bDepartment of Cardiology, Mayo Clinic School of Medicine, Rochester, Minnesota
- cDepartment of Neurology, West Virginia University School of Medicine, Morgantown, West Virginia
- ↵∗Address for correspondence:
Dr. Mohamad Alkhouli, West Virginia University Heart & Vascular Institute, 1 Medical Drive, Morgantown, West Virginia 26505.
Objectives This study aimed to investigate whether the excess morbidity and mortality of atrial fibrillation (AF)–related stroke persists in the contemporary era.
Background Acute ischemic stroke (AIS) in patients with AF is associated with worse outcomes than in patients without AF. Stroke prevention strategies in patients with AF have improved over the last decade and AIS-related mortality overall has also declined.
Methods Patients ≥18 years of age who were admitted with AIS between 2003 and 2014 were identified in the National (Nationwide) Inpatient Sample. The study compared crude and propensity score–matched in-hospital morbidity and mortality, cost, length of stay, and discharge dispositions between patients with and without AF.
Results A total of 930,010 patients were admitted with AIS, and 18.2% of these patients had AF. The prevalence of AF in these patients increased from 16.4% in 2003 to 20.4% in 2014, with the greatest increase observed in white and older patients. Propensity score matching attained 2 pairs of 125,203 patients with AIS with and without AF. In these matched cohorts, the mortality rate was higher in patients with AF (9.9% vs. 6.1%; p < 0.001). Ischemic stroke in patients with AF was also associated with higher incidences of acute kidney injury, bleeding and infectious complications, and severe disability. Hospital length of stay was significantly longer, and cost of care was 20% higher in patients with AF.
Conclusions The prevalence of AF in AIS patients continued to rise, particularly in white and older patients. Despite the improvement in AIS-related morality overall, the differential negative impact of AF on the morbidity, mortality, and cost of AIS was steady over the study’s 12-year period.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
All authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Clinical Electrophysiology author instructions page.
- Received January 9, 2018.
- Revision received February 22, 2018.
- Accepted February 22, 2018.
- 2018 American College of Cardiology Foundation
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