Optogenetic Defibrillation of Mouse VT via Patterned Illumination
(A) Triple-barrier illumination strategy (left); propagation of light-induced excitation in channelrhodopsin-2–expressing transgenic mouse heart as rendered via optical mapping (center); corresponding activation map (right). (B) Electrocardiogram signal before, during, and after use of triple-barrier optogenetic stimulation to terminate ventricular tachycardia (VT).
Modified with permission from Crocini et al. (61).