Optogenetic Defibrillation of VT in Mice (In Vitro) and Humans (In Silico)
(A) Electrocardiogram (ECG) signal recorded from ChR2-expressing mouse heart during ventricular tachycardia (VT) initiation (black bar), perpetuation, and successful optogenetic termination (blue). (B, C) Pseudo-ECG from simulated patient heart with no illumination and red-light illumination (red), resulting in VT termination. Yellow triangles indicate electrical stimuli. (D) Snapshots of voltage distribution at instants indicated by dashed lines in panel C; right ventricular wall is cut away for visualization. Red triangles indicate light-induced excitations; black arrows indicate propagating VT wavefronts.