Expression of Light-Sensitive Ion Channels in Cardiac Tissue
(A, B) Light sensitization of wild-type mouse (channelrhodopsin-2 [ChR2]-mCherry) and rat (ChR2-citrine) hearts via systemic injection of ChR2-adeno-associated virus. (C) Selective light sensitization (ChR2-tdTomato) of connexin 40–expressing Purkinje cells in transgenic mouse hearts. Modified with permission from (A) Vogt et al. (24), (B) Nyns et al. (25), and (C) Zaglia et al. (28). IVS = interventricular septum; LV = left ventricle; RV = right ventricle.