Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell–Cell Adhesion Structures
Rene L. Begay, Sharon L. Graw, Gianfranco Sinagra, Angeliki Asimaki, Teisha J. Rowland, Dobromir B. Slavov, Katherine Gowan, Kenneth L. Jones, Francesca Brun, Marco Merlo, Daniela Miani, Mary Sweet, Kalpana Devaraj, Eric P. Wartchow, Marta Gigli, Ilaria Puggia, Ernesto E. Salcedo, Deborah M. Garrity, Amrut V. Ambardekar, Peter Buttrick, T. Brett Reece, Michael R. Bristow, Jeffrey E. Saffitz, Luisa Mestroni and Matthew R.G. Taylor
Electron Microscopy Images of Left Ventricular Cardiac Muscle From Family DNFDC057
(A) Representative images from individual II:2 show disarrayed Z-discs (white arrows). (B) Magnified image of the white box in A, showing a thickened Z-disc pattern. (C and D) Representative TEM images from individual II:1 exhibiting disarray of Z-discs (black arrows). No aggregates are seen in cardiac myocytes. Scale bars: (A) 1 μm, (B) 200 nm, (C and D) 1 μm.