Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell–Cell Adhesion Structures
Rene L. Begay, Sharon L. Graw, Gianfranco Sinagra, Angeliki Asimaki, Teisha J. Rowland, Dobromir B. Slavov, Katherine Gowan, Kenneth L. Jones, Francesca Brun, Marco Merlo, Daniela Miani, Mary Sweet, Kalpana Devaraj, Eric P. Wartchow, Marta Gigli, Ilaria Puggia, Ernesto E. Salcedo, Deborah M. Garrity, Amrut V. Ambardekar, Peter Buttrick, T. Brett Reece, Michael R. Bristow, Jeffrey E. Saffitz, Luisa Mestroni and Matthew R.G. Taylor
Cardiac Tissue Analysis of FLNC Truncation Variant Carrier From Family DNFDC057 (II:2)
(A) Trichrome staining of the left ventricle shows subepicardial interstitial and focal replacement fibrosis and fatty infiltration (circle) in areas containing degenerating cardiac myocytes. Scale bar = 200 μm. (B) Fatty infiltration and mild fibrosis are seen in the right ventricle. Scale bar = 100 μm.