Author + information
- A.T. Altin1,
- V.K. Vurgun1,
- A. Acibuca1,
- M. Kilickap1,
- C. Isikay2,
- O. Akyurek1,
- B. Candemir1,
- I.S. Gul2,
- D.M. Gerede1 and
- C. Erol1
Catheter ablation of atrial fibrillation (AF) is related with tromboembolic complications. We aimed to measure periprocedural serum neuron-specific enolase (NSE) levels, which is known as biomarker of neuronal injury.
Forty three patients with paroxysmal AF underwent pulmonary vein isolation performed with irrigated radiofrequency catheter. A neurological examination was performed pre- and postablation period. Serum NSE levels was determined before and at the and of the ablation, as well as 2hours, 24hours and 48hours after the procedure.
None of the patients developed new neurological deficits. But NSE levels increased after ablation above the upper reference limit of 17ng/ml in 14 patients. No clinical parameters such as age, hypertension, previous history of stroke, diabetes mellitus, CHA2DS2VASc score and atherosclerotic heart disease showed significant correlation with increased NSE. Procedural parameters such as activated clotting time value, total procedure time, electrical cardioversion didn’t correlated with an increased level of NSE (Table 1). Patients with increased NSE levels had larger left atrium.
|Increase of NSE||p value|
|CHA2DS2VASc≥2||18 (69.2%)||8 (30.8%)||0,757|
|minACT≥250||16 (59.3%)||11 (40.7%)||0,137|
|min DBP (mmHg)||50±7,5||50±15||0,414|
|min SBP (mmHg)||80±12,5||80±31,25||0,853|
|Total procedure time (min)||150±57,5||150±65||0,677|
|Cardioversion||5 (45.5%)||6 (54,5%)||0,133|
Parametric variables are demonstrated as median±IQR and non parametric variables demonstrated as n(%) min: minimal, ACT:activated clotting time, DBP: Diastolic blood pressure, SBP: Systolic blood pressure, LA: Left atrium
Serial assessment of serum NSE level may help to predict acute brain injury related to AF ablation in a low price and readily available manner.